Arsenic and the Placental Epigenome: Unlocking the Secrets of Prenatal Exposure
نویسنده
چکیده
Experts suspect that epigenetic changes such as DNA methylation may be involved in adverse health effects associated with fetal arsenic exposure. Previous studies have investigated associations between arsenic exposure and DNA methylation in adult and umbilical cord blood cells.1,2,3 Now researchers present an extensive epigenome-wide analysis of placental DNA methylation in relation to fetal arsenic exposure.
منابع مشابه
A Systems Toxicology Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
BACKGROUND Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome. OBJECTIVE The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways ar...
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